diff --git a/setup.py b/setup.py
index 32e1af8..f7f190f 100644
--- a/setup.py
+++ b/setup.py
@@ -309,9 +309,6 @@ class PyBuildExt(build_ext):
         return sys.platform
 
     def detect_modules(self):
-        # Ensure that /usr/local is always used
-        add_dir_to_list(self.compiler.library_dirs, '/usr/local/lib')
-        add_dir_to_list(self.compiler.include_dirs, '/usr/local/include')
 
         # Add paths specified in the environment variables LDFLAGS and
         # CPPFLAGS for header and library files.
@@ -347,11 +344,6 @@ class PyBuildExt(build_ext):
                     for directory in reversed(options.dirs):
                         add_dir_to_list(dir_list, directory)
 
-        if os.path.normpath(sys.prefix) != '/usr':
-            add_dir_to_list(self.compiler.library_dirs,
-                            sysconfig.get_config_var("LIBDIR"))
-            add_dir_to_list(self.compiler.include_dirs,
-                            sysconfig.get_config_var("INCLUDEDIR"))
 
         try:
             have_unicode = unicode
@@ -361,11 +353,8 @@ class PyBuildExt(build_ext):
         # lib_dirs and inc_dirs are used to search for files;
         # if a file is found in one of those directories, it can
         # be assumed that no additional -I,-L directives are needed.
-        lib_dirs = self.compiler.library_dirs + [
-            '/lib64', '/usr/lib64',
-            '/lib', '/usr/lib',
-            ]
-        inc_dirs = self.compiler.include_dirs + ['/usr/include']
+        lib_dirs = self.compiler.library_dirs
+        inc_dirs = self.compiler.include_dirs
         exts = []
         missing = []
 
